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KMID : 1007519950040040264
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Food Science and Biotechnology
1995 Volume.4 No. 4 p.264 ~ p.267
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Comutagenic Effect of Sodium Chloride in the Salmonella/Mammalian Microsome Assay
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Park, Kun Young
Suh, Myung Ja/Kim, So Hee
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Abstract
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The mutagenic and comutagenic effects of sodium chloride (NaCl) were investigated in Salmonella/mammalian microsome assay system. The comutagenicity of NaCl on N-methyl-N´-nitro-N-nitrosoguanidine (MNNG) along with the inhibiting effect of vitamin C on its comutagenicity was also studied. Whether the activating enzyme mixture (S9 mixture) was absent or present in the system, NaCl revealed a slight mutagenic effect in the Salmonella typhimurium TA100, which exhibits a base-pair substitution mutagen. But the mutagenic effect of NaCl was not shown in the test strain of TA98 that detects a frameshift mutagen, suggesting that NaCl can be a weak base-pair substitution mutagen. NaCl also exhibited enhancing effect of the mutagenicities induced by aflatoxin B₁(AFB₁) and MNNG. Its comutagenicity was remarkable especially on the direct mutagen of MNNG. As the concentrations of NaCl increased the comutagenic effect of NaCl for MNNG increased significantly (p<0.05). The revertant numbers were about 3 times when 15% of NaCl was added to the MNNG in the system compared to MNNG alone. However, vitamin C decreased the comutagenicity of the NaCl on the MNNG mediated mutagenicity.
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KEYWORD
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